Research Studies

There is a growing body of evidence supporting the benefits of S-equol for reducing menopausal symptoms. Listed below are links to some of the latest studies on S-equol for menopausal symptom solution.

Pharmacokinetics and Metabolism

• Gut bacterial metabolism of the soy isoflavone daidzen: Exploring the relevance to human health.
  Atkinson C, et al. Exp Biol Med 2005; 230:155-170.
• Demographic, anthropometric, and lifestyle factors and dietary intakes in relation to daidzein metabolizing phenotypes among premenopausal women in the United States.
  Atkinson C, et al. Am J Clin Nutr 2008; 87:679-687.
• Equol: History, chemistry and formation.
  Setchell KR and Clerici C. J Nutr 2010; 140:1355S-1362S.
• Equol: Pharmacokinteics and biological actions.
  Setchell KR and Clerici C. J Nutr 2010; 140:1363S-1368S.
• The pharmacokinetics of S-(-)equol administered as SE5-OH tablets to healthy postmenopausal women.
  Setchell KR, et al. Nov 2009; 139 (11): 2037-43.
• Method of defining equol-producer status and its frequency among vegetarians.
  Setchell KR and Cole S. J Nutr 2006; 136:2188-93.
• The clinical importance of the metabolite equol — a clue to the effectiveness of soy and its isoflavones.
  Setchell KR, et al. J Nutr 2002; 132-3577-84.
• Pharmacokinetics of an equol supplement in humans.
  Watanabe S, et al. Anti Aging Med 2007; 4:57-62.

Menopausal Symptoms

• S-equol: A Potential Nonhormonal Agent for Menopause-Related Symptom Relief
  Utian Wulf H, Jones Michelle, and Setchell Kenneth D. R.. Journal of Women's Health. Volume 24 Issue 3: March 11, 2015
• Equol improves menopausal symptoms in Japanese women.
  Aso T. J Nutr 2010; 140:1386S-1384S.
• The physiological effects of Natural S-equol tablets on menopausal symptoms of Japanese post-menopausal women.
  Aso T, et al. NAMS 20th Annual Meeting, Sept. 2009, San Diego, CA; Abstract S-12, 33.
• New equol supplement for relieving menopausal symptoms: Randomized, placebo-controlled trial of Japanese women.
  Ishiwata, N., et al. Menopause 2009; 16:141-148.
• Menopausal hot flashes: A review of physiology and biosociocultural perspective on methods of assessment.
  Kronenberg, F. J Nutr 2010; 140:1380S-1385S.
• A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency and other menopausal symptoms.
  Jenks, B. et al. J of Women's Health 2012; 21(6):674-82
• Equol status and relevance to women's health and menopause.
  Jenks BH, et al. American Academy of Nurse Practitioners (AANP) Poster, 2009.
• The cross-sectional study of the relationship between soy isoflavones, equol and the menopausal symptoms in Japanese women.
  Uchiyama, S., et al. J Jpn Menopause Soc 2007; 15:28-37.

Bone Health

• Dietary equol and bone metabolism in postmenopausal symptoms of Japanese women and osteoporotic mice.
  Ishimi Y. J Nutr 2010; 140:1373S-1376S.
• Equol, via dietary sources or intestinal production may ameliorate estrogen deficiency induced bone loss.
  Weaver C and Legette L. J Nutr 2010; 140:1377S-1379S.

Other Health Benefits

• Emerging research on equol and cancer.
  Lampe JW. J Nutr 2010; 140:1369S-1372S.
• Cautions and research needs identified at the Equol, Soy, and Menopause Leadership Conference.
  Barnes S and Kim H. J Nutr 2010; 140:1390S-1394S.
• The effects of natural s-equol supplementation on skin aging in post menopausal women.
  Oyama A et al. Menopause 2012; 19(2): 202-10.